{"id":155470,"date":"2024-10-08T09:21:55","date_gmt":"2024-10-08T08:21:55","guid":{"rendered":"https:\/\/www.kidneyresearchuk.org\/?p=155470"},"modified":"2024-10-10T09:00:32","modified_gmt":"2024-10-10T08:00:32","slug":"a-new-treatment-target-for-inherited-childhood-kidney-disease","status":"publish","type":"post","link":"https:\/\/www.kidneyresearchuk.org\/2024\/10\/08\/a-new-treatment-target-for-inherited-childhood-kidney-disease\/","title":{"rendered":"A new treatment target for inherited childhood kidney disease"},"content":{"rendered":"\r\n<p>In recent <a href=\"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.6339\">results <\/a>published in the Journal of Pathology, Dr Jennifer Chandler and the team from University College London (UCL) Great Ormond Street Institute of Child Health, supported by a research grant from Kidney Research UK, have seen that disrupted messaging between kidney filter cells, could be an early feature of a childhood kidney disease and offer a potential treatment target.\u00a0\u00a0<\/p>\r\n<h2>Addressing the unmet need of childhood kidney disease<\/h2>\r\n<p>Not all children with glomerular disease respond to drugs that suppress the immune system, which are currently the main treatment for this group. This can lead to permanent scarring of the tiny filters in the kidney, called glomeruli (a condition known as &#8216;glomerulosclerosis&#8217;). As part of her Kidney Research UK fellowship, Jennie studied some of the biological changes that lead to early kidney damage in children with inherited kidney diseases related to mutations in a gene called Wilms Tumor 1 (WT1).\u00a0<\/p>\r\n<p><img decoding=\"async\" class=\"lazyload\" title=\"Dr Jennifer Chandler\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/2022\/02\/Jennie-Chandler-1-scaled.jpg\" alt=\"Dr Jennifer Chandler in her lab\" width=\"1920\" height=\"2560\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"Dr Jennifer Chandler\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/2022\/02\/Jennie-Chandler-1-scaled.jpg\" alt=\"Dr Jennifer Chandler in her lab\" width=\"1920\" height=\"2560\" \/><\/noscript> Dr Jennifer Chandler<\/p>\r\n<h2>Spotlight on inherited kidney diseases<\/h2>\r\n<p>Changes to the WT1 gene can cause a range of kidney syndromes that result in kidney scarring and eventually, <a href=\"https:\/\/www.kidneyresearchuk.org\/kidney-health-information\/stages-of-kidney-disease\/\">kidney failure<\/a>. It is one of the most common causes of inherited kidney diseases in children. People with Denys-Drash syndrome, caused by a mutation to WT1, experience a range of problems including scarring of the glomeruli, which can lead to a loss of kidney function. In addition, these individuals have a greater chance of developing a rare form of <a href=\"https:\/\/www.kidneyresearchuk.org\/conditions-symptoms\/kidney-cancer\/\">kidney cancer<\/a> known as Wilms Tumor. \u00a0<\/p>\r\n<p>Recognising the need for a new treatment target, Jennie and the team studied the entire network of cells that are found within each kidney filter (or glomerulus), in laboratory models with a WT1 mutation. This allowed them to see how glomerular health is altered during kidney disease and any signaling molecules that are involved.\u00a0<\/p>\r\n<h2>Taking a closer look at kidney cells<\/h2>\r\n<p>Jennie and her team found that a type of cell in the glomerulus called podocytes became damaged early in disease, and that this impacted the health of the cells that make up the glomerular blood vessels (known as the endothelium). These cell-based changes lead to loss of filtering ability and eventual kidney failure.\u00a0<\/p>\r\n<p>When looking more closely at the changes in how cells communicated in this disease model, the research team found that a molecule called adrenomedullin, which is involved in cell growth, was at higher-than expected levels.\u00a0<\/p>\r\n<h2>Exploring the effect of adrenomedullin on kidney filter health<\/h2>\r\n<p>Investigating this further, the researchers found that higher levels of adrenomedullin were common where there was damage to kidney cells. The team found that by increasing the levels further, improvements could be made to the health of the filter cells.\u00a0<\/p>\r\n<p><img decoding=\"async\" class=\"lazyload\" title=\"2 healthy glomeruli_green blood vessles\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/2024\/10\/2-healthy-glomeruli_green-blood-vessles-scaled.jpg\" alt=\"A microscopic image of a cell which has bright blue blobs and bright green sections around the blobs\" width=\"2560\" height=\"2560\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"2 healthy glomeruli_green blood vessles\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/2024\/10\/2-healthy-glomeruli_green-blood-vessles-scaled.jpg\" alt=\"A microscopic image of a cell which has bright blue blobs and bright green sections around the blobs\" width=\"2560\" height=\"2560\" \/><\/noscript> Two healthy human glomeruli, where the balls of green staining show all the blood vessels in the glomeruli (called the endothelium)<\/p>\r\n<h2>What does this mean for kidney patients?<\/h2>\r\n<p>By understanding the pathways that lead to damage to the kidney filters during childhood kidney disease in more detail, Jennie and her team have identified a potential alternative approach to treat children with kidney disease who do not respond to classic therapy.\u00a0<\/p>\r\n<blockquote>\r\n<p>&#8220;This research takes us one step closer to identifying a new treatment strategy to prevent kidney failure in children and I am really pleased that we now have Kidney Research UK funding for a PhD student, Emily Moore to continue this work. This opportunity builds capacity into renal research and will allow us to understand more about the effects of adrenomedullin and its therapeutic potential.&#8221; Dr Jennifer Chandler<\/p>\r\n<\/blockquote>\r\n<h2>Read our latest research news<\/h2>\r\n<p><img decoding=\"async\" class=\"lazyload\" title=\"General image of normothermic perfusion equipment\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Normothermic-perfusion-equipment-500x333-landscape-e263c55df571ae42be7db7c67be4590e-.jpg\" alt=\"equipment in a lab that is used for normothermic perfusion\" width=\"500\" height=\"333\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"General image of normothermic perfusion equipment\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Normothermic-perfusion-equipment-500x333-landscape-e263c55df571ae42be7db7c67be4590e-.jpg\" alt=\"equipment in a lab that is used for normothermic perfusion\" width=\"500\" height=\"333\" data-no-lazy=\"1\" \/><\/noscript><\/p>\r\n<h3>Can we remove white blood cells from donor kidneys to protect them from early transplant rejection?<\/h3>\r\n<p>2 October 2024<img decoding=\"async\" class=\"lazyload\" title=\"DD24 posters\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/DD24-posters-scaled-e1727259502387-500x353-landscape-5f15f1dbd28687d0ec930f2484176d95-.jpg\" alt=\"Delegates at the Driving Discoveries conference viewing research posters during the coffee break\" width=\"500\" height=\"353\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"DD24 posters\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/DD24-posters-scaled-e1727259502387-500x353-landscape-5f15f1dbd28687d0ec930f2484176d95-.jpg\" alt=\"Delegates at the Driving Discoveries conference viewing research posters during the coffee break\" width=\"500\" height=\"353\" data-no-lazy=\"1\" \/><\/noscript><\/p>\r\n<h3>Driving Discoveries 2024: accelerating research<\/h3>\r\n<p>25 September 2024<img decoding=\"async\" class=\"lazyload\" title=\"Prof Moin Saleem\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Prof-Saleem-500x334-landscape-a3d0cef577c39b69c193ce6b54784503-.jpg\" alt=\"Main wearing black jumper and blue jacket\" width=\"500\" height=\"334\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"Prof Moin Saleem\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Prof-Saleem-500x334-landscape-a3d0cef577c39b69c193ce6b54784503-.jpg\" alt=\"Main wearing black jumper and blue jacket\" width=\"500\" height=\"334\" data-no-lazy=\"1\" \/><\/noscript><\/p>\r\n<h3>New resource aims to support more precise approaches to diagnosing and treating idiopathic nephrotic syndrome<\/h3>\r\n<p>16 September 2024<img decoding=\"async\" class=\"lazyload\" title=\"Professor Reza Motallebzadeh\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Professor-Reza-Motallebzadeh-500x281-landscape-e6237d1993d07ad61c23ba700eea61ca-.jpg\" alt=\"Man wearing a light blue shirt and navy blazer\" width=\"500\" height=\"281\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"Professor Reza Motallebzadeh\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Professor-Reza-Motallebzadeh-500x281-landscape-e6237d1993d07ad61c23ba700eea61ca-.jpg\" alt=\"Man wearing a light blue shirt and navy blazer\" width=\"500\" height=\"281\" data-no-lazy=\"1\" \/><\/noscript><\/p>\r\n<h3>Can a type of immune cells found in the kidney control viral infections in patients who receive a transplant?<\/h3>\r\n<p>9 August 2024<img decoding=\"async\" class=\"lazyload\" title=\"mufid-majnun-X4Hypm5HBfA-unsplash\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/mufid-majnun-X4Hypm5HBfA-unsplash-500x333-landscape-48bd66835b11c48fe342b7df767b9205-.jpg\" alt=\"person in pink long sleeve shirt holding white samsung android smartphone\" width=\"500\" height=\"333\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"mufid-majnun-X4Hypm5HBfA-unsplash\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/mufid-majnun-X4Hypm5HBfA-unsplash-500x333-landscape-48bd66835b11c48fe342b7df767b9205-.jpg\" alt=\"person in pink long sleeve shirt holding white samsung android smartphone\" width=\"500\" height=\"333\" data-no-lazy=\"1\" \/><\/noscript><\/p>\r\n<h3>Research team in Manchester discover that kidney genes may lead to high blood pressure and that cells found in the urine could help to diagnose kidney disease early on<\/h3>\r\n<p>8 August 2024<img decoding=\"async\" class=\"lazyload\" title=\"Oplus_34\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Dominic-headshot-314x500-landscape-6a51120ce4b8edbb593222c5a1e58d3a-.jpg\" alt=\"Man wearing black glasses and a brown shirt.\" width=\"314\" height=\"500\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"Oplus_34\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Dominic-headshot-314x500-landscape-6a51120ce4b8edbb593222c5a1e58d3a-.jpg\" alt=\"Man wearing black glasses and a brown shirt.\" width=\"314\" height=\"500\" data-no-lazy=\"1\" \/><\/noscript><\/p>\r\n<h3>Understanding access to SGLT2 inhibitors<\/h3>\r\n<p>5 August 2024<img decoding=\"async\" class=\"lazyload\" title=\"Cambridge dialysis unit shoot June 2021 (8)\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Cambridge-dialysis-unit-shoot-June-2021-8-500x359-landscape-a48d6ba5b71f30cfcc075d5b872a76c9-.jpg\" alt=\"Nurse working on a computer in the dialysis unit with patients in the background and Kidney Research UK hoodie on the back of chair\" width=\"500\" height=\"359\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"Cambridge dialysis unit shoot June 2021 (8)\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Cambridge-dialysis-unit-shoot-June-2021-8-500x359-landscape-a48d6ba5b71f30cfcc075d5b872a76c9-.jpg\" alt=\"Nurse working on a computer in the dialysis unit with patients in the background and Kidney Research UK hoodie on the back of chair\" width=\"500\" height=\"359\" data-no-lazy=\"1\" \/><\/noscript><\/p>\r\n<h3>\u201cAs nurses, our research aligns with patient views&#8221;<\/h3>\r\n<p>1 August 2024<img decoding=\"async\" class=\"lazyload\" title=\"John Fallon\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Portrait-photo-John-375x500-landscape-3d7cb1662ddee1a75e519ef087260d46-.jpg\" alt=\"Male with beard wearing red scrubs\" width=\"375\" height=\"500\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"John Fallon\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Portrait-photo-John-375x500-landscape-3d7cb1662ddee1a75e519ef087260d46-.jpg\" alt=\"Male with beard wearing red scrubs\" width=\"375\" height=\"500\" data-no-lazy=\"1\" \/><\/noscript><\/p>\r\n<h3>Can we improve the condition of damaged donor kidneys and make more available for transplantation?<\/h3>\r\n<p>22 July 2024<img decoding=\"async\" class=\"lazyload\" title=\"Adrian woolf1\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Adrian-woolf1-500x283-landscape-cb319e0e5200a7ac61c24b3973affb24-.jpg\" alt=\"Professor Adrian Woolf\" width=\"500\" height=\"283\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"Adrian woolf1\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Adrian-woolf1-500x283-landscape-cb319e0e5200a7ac61c24b3973affb24-.jpg\" alt=\"Professor Adrian Woolf\" width=\"500\" height=\"283\" data-no-lazy=\"1\" \/><\/noscript><\/p>\r\n<h3>New approaches in inherited kidney diseases &#8211; how close are we to growing new kidneys and replacing faulty genes?<\/h3>\r\n<p>19 July 2024<img decoding=\"async\" class=\"lazyload\" title=\"220906_Kidney_Research_UK_10340 (1)\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/220906_Kidney_Research_UK_10340-1-500x333-landscape-6b0a324fb96f3cd9738d33658eeb4fcc-.jpg\" alt=\"Professor John Stone and researcher in the lab\" width=\"500\" height=\"333\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"220906_Kidney_Research_UK_10340 (1)\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/220906_Kidney_Research_UK_10340-1-500x333-landscape-6b0a324fb96f3cd9738d33658eeb4fcc-.jpg\" alt=\"Professor John Stone and researcher in the lab\" width=\"500\" height=\"333\" data-no-lazy=\"1\" \/><\/noscript><\/p>\r\n<h3>Identifying differences between centres in outcomes following kidney transplant failure<\/h3>\r\n<p>17 July 2024<img decoding=\"async\" class=\"lazyload\" title=\"Katherine Bull - human kidney cells (1)\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Katherine-Bull-human-kidney-cells-1-500x264-landscape-d9723c250f069b267f68745ce813b533-.png\" alt=\"Microscopic images of coloured kidney cells which are blue, green and purple\" width=\"500\" height=\"264\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"Katherine Bull - human kidney cells (1)\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Katherine-Bull-human-kidney-cells-1-500x264-landscape-d9723c250f069b267f68745ce813b533-.png\" alt=\"Microscopic images of coloured kidney cells which are blue, green and purple\" width=\"500\" height=\"264\" data-no-lazy=\"1\" \/><\/noscript><\/p>\r\n<h3>New mathematical methods used as predictive tools during kidney biopsies, leading to more personalised treatment<\/h3>\r\n<p>16 July 2024<img decoding=\"async\" class=\"lazyload\" title=\"BK-images\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/BK-images-500x170-landscape-c197971249aebe5a369d761968db19bb-.jpg\" alt=\"Images of the BK virus\" width=\"500\" height=\"170\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"BK-images\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/BK-images-500x170-landscape-c197971249aebe5a369d761968db19bb-.jpg\" alt=\"Images of the BK virus\" width=\"500\" height=\"170\" data-no-lazy=\"1\" \/><\/noscript><\/p>\r\n<h3>Finding new treatments for BK virus infection in kidney transplant patients<\/h3>\r\n<p>11 July 2024<img decoding=\"async\" class=\"lazyload\" title=\"group\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/group-500x375-landscape-17fee590afe04b0ef80896373e40febe-.jpg\" alt=\"five females taking a selfie\" width=\"500\" height=\"375\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"group\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/group-500x375-landscape-17fee590afe04b0ef80896373e40febe-.jpg\" alt=\"five females taking a selfie\" width=\"500\" height=\"375\" data-no-lazy=\"1\" \/><\/noscript><\/p>\r\n<h3>Our team head to Edinburgh for UK Kidney Week<\/h3>\r\n<p>21 June 2024<img decoding=\"async\" class=\"lazyload\" title=\"Surgeon with organ donation\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Transplant-18034608-500x323-landscape-b049e596143d936b13e899ae17fb3c33-.jpg\" alt=\"surgeon with his fresh delivery\" width=\"500\" height=\"323\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"Surgeon with organ donation\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Transplant-18034608-500x323-landscape-b049e596143d936b13e899ae17fb3c33-.jpg\" alt=\"surgeon with his fresh delivery\" width=\"500\" height=\"323\" data-no-lazy=\"1\" \/><\/noscript><\/p>\r\n<h3>Finding new ways to protect transplanted kidneys<\/h3>\r\n<p>20 June 2024<img decoding=\"async\" class=\"lazyload\" title=\"DF headshot 2023\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/DF-headshot-2023-500x281-landscape-57ad99f67dd6b209290593790ed1b0df-.png\" alt=\"A male, wearing a white shirt, leaning up against a wall\" width=\"500\" height=\"281\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"DF headshot 2023\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/DF-headshot-2023-500x281-landscape-57ad99f67dd6b209290593790ed1b0df-.png\" alt=\"A male, wearing a white shirt, leaning up against a wall\" width=\"500\" height=\"281\" data-no-lazy=\"1\" \/><\/noscript><\/p>\r\n<h3>Investigating the impact of haemodialysis on response to vaccination and infection<\/h3>\r\n<p>19 June 2024<img decoding=\"async\" class=\"lazyload\" title=\"Rebecca Walker 2024\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Rebecca-Walker-2024-375x500-landscape-7c50659af34b3f63fcd28c52792e0b78-.jpg\" alt=\"Female research standing in front of her lab bench\" width=\"375\" height=\"500\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"Rebecca Walker 2024\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Rebecca-Walker-2024-375x500-landscape-7c50659af34b3f63fcd28c52792e0b78-.jpg\" alt=\"Female research standing in front of her lab bench\" width=\"375\" height=\"500\" data-no-lazy=\"1\" \/><\/noscript><\/p>\r\n<h3>Studying how communication between cells can lead to cyst development in autosomal recessive polycystic kidney disease (ARPKD).<\/h3>\r\n<p>12 June 2024<img decoding=\"async\" class=\"lazyload\" title=\"HCMVinfectedcell\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/HCMVinfectedcell-500x340-landscape-f94140c4ee5610bb7a32f515c853e754-.jpg\" alt=\"Black and white image of CMV cells\" width=\"500\" height=\"340\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"HCMVinfectedcell\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/HCMVinfectedcell-500x340-landscape-f94140c4ee5610bb7a32f515c853e754-.jpg\" alt=\"Black and white image of CMV cells\" width=\"500\" height=\"340\" data-no-lazy=\"1\" \/><\/noscript><\/p>\r\n<h3>Protecting vulnerable individuals from cytomegalovirus: a new approach<\/h3>\r\n<p>12 June 2024<img decoding=\"async\" class=\"lazyload\" title=\"Microscopic image\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Weavers-Kidney-image-500x178-landscape-857f0dbbdd5b14b776b6ae66c3a1302c-.jpg\" alt=\"Image from under a microscope which is purple with pink and blue\" width=\"500\" height=\"178\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"Microscopic image\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Weavers-Kidney-image-500x178-landscape-857f0dbbdd5b14b776b6ae66c3a1302c-.jpg\" alt=\"Image from under a microscope which is purple with pink and blue\" width=\"500\" height=\"178\" data-no-lazy=\"1\" \/><\/noscript><\/p>\r\n<h3>Understanding kidney disease risk and treatment possibilities using a new laboratory model<\/h3>\r\n<p>12 June 2024<img decoding=\"async\" class=\"lazyload\" title=\"Dr Samira Bell\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/SB_IMG_5638-363x500-landscape-0559efd445c7182121c454167a0ef1d5-.jpg\" alt=\"Headshot of female with brown hair wearing a white shirt and blue jacket\" width=\"363\" height=\"500\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"Dr Samira Bell\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/SB_IMG_5638-363x500-landscape-0559efd445c7182121c454167a0ef1d5-.jpg\" alt=\"Headshot of female with brown hair wearing a white shirt and blue jacket\" width=\"363\" height=\"500\" data-no-lazy=\"1\" \/><\/noscript><\/p>\r\n<h3>New data science \u2018catalyst&#8217; aims to transform kidney patients&#8217; lives<\/h3>\r\n<p>4 June 2024<img decoding=\"async\" class=\"lazyload\" title=\"Professor Rachel Lennon\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Dr-Rachel-Lennon-500x333-landscape-4ee51d26ec4f0ea31662c01a8f457fb4-.jpg\" alt=\"Professor Rachel Lennon, funded researcher\" width=\"500\" height=\"333\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"Professor Rachel Lennon\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Dr-Rachel-Lennon-500x333-landscape-4ee51d26ec4f0ea31662c01a8f457fb4-.jpg\" alt=\"Professor Rachel Lennon, funded researcher\" width=\"500\" height=\"333\" data-no-lazy=\"1\" \/><\/noscript><\/p>\r\n<h3>Uniting to meet the challenge of Alport syndrome<\/h3>\r\n<p>31 May 2024<\/p>\r\n<!-- .pp-content-posts -->\r\n<h2>Why not make a donation now?<\/h2>\r\n<p>(Every \u00a3 counts)<\/p>\r\n<p><a href=\"https:\/\/kidneyresearchuk.org\/support\/donate\/\" target=\"_self\" rel=\"noopener\"> Donate now <\/a><\/p>\r\n","protected":false},"excerpt":{"rendered":"<p>In recent results published in the Journal of Pathology, Dr Jennifer Chandler and the team from University College London (UCL) Great Ormond Street Institute of Child Health, supported by a research grant from Kidney Research UK, have seen that disrupted messaging between kidney filter cells, could be an early feature of a childhood kidney disease&hellip;<\/p>\n","protected":false},"author":3,"featured_media":82192,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_searchwp_excluded":"","footnotes":""},"categories":[336,29],"tags":[],"class_list":["post-155470","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-paediatric","category-research"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>A new treatment target for inherited childhood kidney disease - Kidney Research 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